Mayo Clinic

Shane A. Shapiro is a consultant in the Department of Orthopedic Surgery in Florida, where he serves as the medical director of the Regenerative Medicine Therapeutics Program, Mayo Clinic Center for Regenerative Medicine.

Dr. Shapiro joined the staff of Mayo Clinic in 2005 and holds the academic rank of associate professor of orthopedic surgery, Mayo Clinic College of Medicine and Science. Dr. Shapiro completed his undergraduate studies at Brown University and earned his M.D. from the University of Virginia School of Medicine, with residency and fellowship at Mayo Clinic in Florida.

Dr. Shapiro specializes in the nonsurgical management of musculoskeletal injuries while also advancing the science of orthopedics and regenerative medicine through research. He is the principal investigator of the world’s first randomized controlled study of bone marrow-derived stem cells to treat knee arthritis. Early in his career, he was a member of the NIH laboratory that worked on the Human Genome Project to map every gene in the human body.

Dr. Shapiro’s current research is the study of novel regenerative techniques for nonhealing bone, joint, muscle, tendon and skin maladies that are not candidates for conventional surgical management. Examples include cell and cell-derived therapy for arthritis, platelet rich plasma injections for chronic tendinopathies, and the use of living, cell-based biological applications for chronic nonhealing wounds. As such, he is the sponsor investigator of 4 FDA Investigational New Drug (IND) applications for human cell therapy products. These strategies form the foundation upon which the future of cell-based therapies for orthopedic disease will be built.

As medical director for the Regenerative Medicine Therapeutics Program in Florida, Dr. Shapiro has broadened the scope of his research to forge collaborations between medical specialties. Such partnerships have resulted in cell therapy to treat baldness and gastrointestinal disorders as well as upcoming projects involving glioblastoma, urologic conditions, and lower extremity wounds.


Florida Organization for Regenerative Medicine

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